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GameMastery Guide / Getting Started / Creating a Campaign Guide

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Source GameMastery Guide pg. 20
The default assumption is that your game will use the rules as presented in the Pathfinder RPG Core Rulebook. Many GMs customize the Core Rules to fit their preferences, play style, and players, and the campaign guide is the perfect place to set out these custom house rules so the players know what to expect and so customizations or exceptions remain consistent throughout the campaign. You’ll also want to lay out character creation guidelines for the game and clarify what is expected or prohibited, so players know their choices going into the process of designing their characters.

For example, you might ban a particular sorcerer bloodline or other character option simply because it doesn’t fit into the setting and does not exist there (at least so far as anybody knows). On the other hand, you can set up a rule that PCs cannot be assassins or choose evil as their alignment because you’d rather not deal with the complications those possibilities entail. That doesn’t necessarily mean assassins and evil alignments don’t exist in the setting; they’re just not an option for the players.