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Curses in your Game

Source Horror Adventures pg. 138
Curses can afflict characters in a variety of ways, but because they are perniciously difficult to remove, the tone of the game can shift if they appear often. Most curses—especially those that require more than a simple remove curse spell to eliminate—should be used to add a significant and memorable challenge or as a consequence for a momentous choice. A relentless torrent of curses reduces their mystique while dramatically hampering a party’s effectiveness, potentially removing the PCs’ ability to deal with encounters of appropriate Challenge Ratings.